業績紹介

主要論文　（* corresponding author, † equally contribution）

2024

Gao P, Inada Y, Hotta A, Sakurai H, Ikeya M*.
iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.
Stem Cell Res Ther. 2024 Mar 18;15(1):83. doi: 10.1186/s13287-024-03691-7. PMID: 38500216 Free PMC article. [Journal HP][CiRA HP]

2023

Zhao C, Inada Y, Sekiguchi K, Hino K, Nishio M, Yamada Y, Matsuda S, Toguchida J, Ikeya M*
Myelin protein zero (P0)- and Wnt1-Cre marked muscle resident neural crest-derived mesenchymal progenitor cells give rise to heterotopic ossification in mouse models.

Genes Dis. 2023 May 29:10(3)731-734. doi: 10.1016/j.gendis.2022.09.002. PMID: 37396524 [Journal HP][CiRA HP]

Zujur D, Al-Akashi Z, Nakamura A, Zhao C, Takahashi K, Aritomi S, Theoputra W, Kamiya D, Nakayama K, Ikeya M*.
Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair.

Front Cell Dev Biol. 2023 May 10;11:1140717. doi: 10.3389/fcell.2023.1140717. eCollection 2023.
PMID: 37234772 [Journal HP][CiRA HP]

Al-Akashi Z, Zujur D, Kamiya D, Kato T Jr, Kondo T, Ikeya M*.
Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification.

Front Cell Dev Biol. 2023 Feb 6;11:1089945. doi: 10.3389/fcell.2023.1089945. eCollection 2023. PMID: 36814599 Free PMC article. [Journal HP][CiRA HP]

2022
Kamiya D, Takenaka-Ninagawa N, Motoike S, Kajiya M, Akaboshi T, Zhao C, Shibata M, Senda S, Toyooka Y, Sakurai H, Kurihara H, Ikeya M*.
Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage.
NPJ Regen Med. 2022 Sep 15;7(1):47. doi: 10.1038/s41536-022-00241-8. PMID: 36109564 [Journal HP][紹介動画][CiRA HP]

Kamiya D†*, Yamashita T†, Akaboshi T, Yamaguchi Y, Toyooka Y, Ikeya M.

Generation of human GAPDH knock-in reporter iPSC lines for stable expression of tdTomato in pluripotent and differentiated culture conditions.
Stem Cell Res. 2022 Feb 8;60:102704. doi: 10.1016/j.scr.2022.102704. Online ahead of print. PMID: 35176664 [Journal HP]

Yamashita T†, Kamiya D†, Kawaraichi N, Toyokawa H, Akaboshi T, Ikeya M, Toyooka Y*.
Generation of a human SOX10 knock-in reporter iPSC line for visualization of neural crest cell differentiation.
Stem Cell Res. 2022 Feb 1;60:102696. doi: 10.1016/j.scr.2022.102696. Online ahead of print. PMID: 35144211 [Journal HP]

2021

Nakajima T*, Nakahata A, Yamada N, Yoshizawa K, Kato TM, Iwasaki M, Zhao C, Kuroki H, Ikeya M*.
Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture.

Nat Commun. 2021 Aug 18;12(1):5012. doi: 10.1038/s41467-021-25328-6. PMID: 34408142 [Journal HP]

2020

Mitsuzawa S†, Zhao C†, Ikeguchi R*, Aoyama T, Kamiya D, Ando M, Takeuchi H, Akieda S, Nakayama K, Matsuda S, Ikeya M*.

Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration.

Sci Rep. 2020 Jul 21;10(1):12034. doi: 10.1038/s41598-020-68745-1. PMID: 32694698 [CiRA HP] [Journal HP]

2019
Nakajima T*, Sakurai H, Ikeya M*.
In Vitro Generation of Somite Derivatives from Human Induced Pluripotent Stem Cells.
J Vis Exp. 2019 Apr 25; 146: e59359, doi:10.3791/59359 [Journal HP] [Journal HP]

2018
Hino K†, Zhao C†, Horigome K, Nishio M, Okanishi Y, Nagata S, Komura S, Yamada Y, Toguchida J, Ohta A, Ikeya M*.
An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva.
Stem Cell Reports. 2018 Nov 13;11(5):1106-1119. doi: 10.1016/j.stemcr.2018.10.007. [CiRA HP] [Journal HP]

Nakajima T, Shibata M, Nishio M, Nagata S, Alev C, Sakurai H, Toguchida J, Ikeya M*.
Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells

Development. 2018 Aug 23; 145: dev165431 doi: 10.1242/dev.165431. [CiRA HP] [Journal HP]

2017
Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, Jin Y, Kawakami K, Yamada Y, Ohta A, Toguchida J*, Ikeya M*.
Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.

J Clin Invest. 2017 Sep 1;127(9):3339-3352. doi: 10.1172/JCI93521. Epub 2017 Jul 31. [CiRA HP] [Journal HP]

2015
Hino K, Ikeya M*, Horigome K, Matsumoto Y, Ebise H, Nishio M, Sekiguchi K, Shibata M, Nagata S, Matsuda S, Toguchida J*.
Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15438-43. doi: 10.1073/pnas.1510540112. Epub 2015 Nov 30. [CiRA HP] [Journal HP]

Matsumoto Y†, Ikeya M†*, Hino K, Horigome K, Fukuta M, Watanabe M, Nagata S, Yamamoto T, Otsuka T, Toguchida J*.
New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva.

Stem Cells. 2015 Jun;33(6):1730-42. doi: 10.1002/stem.1981. [CiRA HP] [Journal HP]

Yokoyama K, Ikeya M, Umeda K, Oda H, Nodomi S, Nasu A, Matsumoto Y, Izawa K, Horigome K, Kusaka T, Tanaka T, Saito MK, Yasumi T, Nishikomori R, Ohara O, Nakayama N, Nakahata T, Heike T, Toguchida J.
Enhanced chondrogenesis of iPS cells from neonatal-onset multisystem inflammatory disease occurs via the caspase-1-independent cAMP/PKA/CREB pathway.

Arthritis Rheumatol. 2015 Jan;67(1):302-14. doi: 10.1002/art.38912. [CiRA HP] [Journal HP]

2014
Fukuta M†, Nakai Y†, Kirino K†, Nakagawa M, Sekiguchi K, Nagata S, Matsumoto Y, Yamamoto T, Umeda K, Heike T, Okumura N, Koizumi N, Sato T, Nakahata T, Saito M, Otsuka T, Kinoshita S, Ueno M*, Ikeya M*, Toguchida J*.
Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media.

PLoS One. 2014 Dec 2;9(12):e112291. doi: 10.1371/journal.pone.0112291. eCollection 2014. [CiRA HP] [Journal HP]

2013
Matsumoto Y†, Hayashi Y†, Schlieve CR†, Ikeya M*, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J*, Hsiao EC*
Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.

Orphanet J Rare Dis. 2013 Dec 9;8:190. doi: 10.1186/1750-1172-8-190. [CiRA HP] [Journal HP]

Hayakawa K, Ikeya M, Fukuta M, Woltjen K, Tamaki S, Takahara N, Kato T Jr, Sato S, Otsuka T, Toguchida J.
Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells. Biochem

Biochem Biophys Res Commun. 2013 Mar 22;432(4):713-9. doi: 10.1016/j.bbrc.2013.01.003. Epub 2013 Jan 10. [Journal HP]

Nasu A, Ikeya M, Yamamoto T, Watanabe A, Jin Y, Matsumoto Y, Hayakawa K, Amano N, Sato S, Osafune K, Aoyama T, Nakamura T, Kato T, Toguchida J.
Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin.

PLoS One. 2013;8(1):e53771. doi: 10.1371/journal.pone.0053771. Epub 2013 Jan 31. [Journal HP]

2010以前
Ikeya M*, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y.
Cv2, Functioning as a Pro-BMP Factor via Twisted Gastrulation, is Required for Early Development of Nephron Precursors.

Dev. Biol. 337, 405-414 (2010) [CDB HP] [Journal HP]

Ikeya M*, Nosaka T, Fukushima K, Kawada M, Furuta Y, Kitamura T, Sasai Y.
Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice.

Mech. Dev. 125, 832-842 (2008) [CDB HP] [Journal HP]

Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y.
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.

Development 133, 4463-4473 (2006) [CDB HP] [Journal HP]

Ikeya M*, Kawada M, Nakazawa Y, Sakuragi M, Sasai N, Ueno M, Kiyonari H, Nakao K, Sasai Y.
Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations.

Int. J. Dev. Biol. 49, 807-823 (2005) [Journal HP]

Ikeya M, Takada S.
Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression.

Mech. Dev. 103, 27-33 (2001) [Journal HP]

Ikeya M, Takada S.
Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.

Development 125, 4969-4976 (1998) [Journal HP]

Ikeya M, Lee SM, Johnson JE, McMahon AP, Takada S.
Wnt signalling required for expansion of neural crest and CNS progenitors.

Nature 389, 966-970 (1997) [Journal HP]

共著論文

2023

Aoi T, Tanaka A, Furuhashi K, Ikeya M, Shimizu A, Arioka Y, Kushima I, Ozaki N, Maruyama S.
Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence.

Nagoya J Med Sci. 2023 Nov;85(4):682-690. doi: 10.18999/nagjms.85.4.682. PMID: 38155616 Free PMC article.

Mizuno K, Ohnishi H, Yoshimatsu M, Zhao C, Hayashi Y, Kuwata F, Kaba S, Okuyama H, Kawai Y, Hiwatashi N, Kishimoto Y, Sakamoto T, Ikeya M, Omori K.
Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells.
Cell Transplant. 2023 Jan-Dec;32:9636897231178460. doi: 10.1177/09636897231178460. PMID: 37278405

2021

Harada A, Goto M, Kato A, Takenaka-Ninagawa N, Tanaka A, Noguchi S, Ikeya M, Sakurai H.
Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice.
Front Cell Dev Biol. 2021 Nov 23;9:790341. doi: 10.3389/fcell.2021.790341. eCollection 2021. PMID: 34888314

Nakamura A, Murata D, Fujimoto R, Tamaki S, Nagata S, Ikeya M, Toguchida J, Nakayama K.
Bio-3D printing iPSCs-derived human chondrocytes for articular cartilage regeneration.
Biofabrication. 2021 Aug 11. doi: 10.1088/1758-5090/ac1c99. Online ahead of print. PMID: 34380122

Takenaka-Ninagawa N, Kim J, Zhao M, Sato M, Jonouchi T, Goto M, Yoshioka CKB, Ikeda R, Harada A, Sato T, Ikeya M, Uezumi A, Nakatani M, Noguchi S, Sakurai H.
Collagen-VI supplementation by cell transplantation improves muscle regeneration in Ullrich congenital muscular dystrophy model mice.

Stem Cell Res Ther. 2021 Aug 9;12(1):446. doi: 10.1186/s13287-021-02514-3. PMID: 34372931

Yoshimatsu M, Ohnishi H, Zhao C, Hayashi Y, Kuwata F, Kaba S, Okuyama H, Kawai Y, Hiwatashi N, Kishimoto Y, Sakamoto T, Ikeya M, Omori K.
In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells.
Stem Cell Res. 2021 Apr;52:102233. doi: 10.1016/j.scr.2021.102233. Epub 2021 Feb 11. PMID: 33607469

2020
Imhof BA, Ballet R, Hammel P, Jemelin S, Garrido-Urbani S, Ikeya M, Matthes T, Miljkovic-Licina M.

Olfactomedin-like 3 promotes PDGF-dependent pericyte proliferation and migration during embryonic blood vessel formation.
FASEB J. 2020 Nov;34(11):15559-15576. doi: 10.1096/fj.202000751RR. Epub 2020 Sep 30. PMID: 32997357 DOI: 10.1096/fj.202000751RR

Matsuda M, Hayashi H, Garcia-Ojalvo J, Yoshioka-Kobayashi K, Kageyama R, Yamanaka Y, Ikeya M, Toguchida J, Alev C, Ebisuya M.

Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
Science. 2020 Sep 18;369(6510):1450-1455. doi: 10.1126/science.aba7668. PMID: 32943519

Zhao M, Tazumi A, Takayama S, Takenaka-Ninagawa N, Nalbandian M, Nagai M, Nakamura Y, Nakasa M, Watanabe A, Ikeya M, Hotta A, Ito Y, Sato T, Sakurai H.
Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model.

Stem Cell Reports. 2020 Jul 14;15(1):80-94. doi: 10.1016/j.stemcr.2020.06.004. Epub 2020 Jul 2. PMID: 32619494

Matsuda M, Yamanaka Y, Uemura M, Osawa M, Saito MK, Nagahashi A, Nishio M, Guo L, Ikegawa S, Sakurai S, Kihara S, Maurissen TL, Nakamura M, Matsumoto T, Yoshitomi H, Ikeya M, Kawakami N, Yamamoto T, Woltjen K, Ebisuya M, Toguchida J, Alev C.

Recapitulating the human segmentation clock with pluripotent stem cells.
Nature. 2020 Apr;580(7801):124-129. doi: 10.1038/s41586-020-2144-9. Epub 2020 Apr 1. PMID: 32238941

Tsujimoto H, Kasahara T, Sueta SI, Araoka T, Sakamoto S, Okada C, Mae SI, Nakajima T, Okamoto N, Taura D, Nasu M, Shimizu T, Ryosaka M, Li Z, Sone M, Ikeya M, Watanabe A, Osafune K.

A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells.
Cell Rep. 2020 Apr 7;31(1):107476. doi: 10.1016/j.celrep.2020.03.040. PMID: 32268094 [Journal HP]

2019

Mitsuzawa S, Ikeguchi R, Aoyama T, Ando M, Takeuchi H, Yurie H, Oda H, Noguchi T, Ohta S, Zhao C, Ikeya M, Matsuda S.
Induced pluripotent stem cell-derived mesenchymal stem cells prolong hind limb survival in a rat vascularized composite allotransplantation model.

Microsurgery. 2019 Nov;39(8):737-747. doi: 10.1002/micr.30507. Epub 2019 Aug 31. PMID: 31471984 [Journal HP]

Motoike S, Kajiya M, Komatsu N, Horikoshi S, Ogawa T, Sone H, Matsuda S, Ouhara K, Iwata T, Mizuno N, Fujita T, Ikeya M, Kurihara H.

Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis.
Int J Mol Sci. 2019 Aug 15;20(16). pii: E3970. doi: 10.3390/ijms20163970. PMID: 31443173 [Journal HP]

Katsuno T, Belyantseva IA, Cartagena-Rivera AX, Ohta K, Crump SM, Petralia RS, Ono K, Tona R, Imtiaz A, Rehman A, Kiyonari H, Kaneko M, Wang YX, Abe T, Ikeya M, Fenollar-Ferrer C, Riordan GP, Wilson EA, Fitzgerald TS, Segawa K, Omori K, Ito J, Frolenkov GI, Friedman TB, Kitajiri SI.

TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing.

JCI Insight. 2019 Jun 20;4(12):e128561. doi: 10.1172/jci.insight.128561. eCollection 2019 Jun 20. PMID: 31217345

Kawai S, Yoshitomi H, Sunaga J, Alev C, Nagata S, Nishio M, Hada M, Koyama Y, Uemura M, Sekiguchi K, Maekawa H, Ikeya M, Tamaki S, Jin Y, Harada Y, Fukiage K, Adachi T, Matsuda S, Toguchida J.
In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes.

Nat Biomed Eng. 2019 Jul;3(7):558-570. doi: 10.1038/s41551-019-0410-7. Epub 2019 Jun 10. PMID: 31182836

Iwashita M, Ohta H, Fujisawa T, Cho M, Ikeya M, Kidoaki S, Kosodo Y.
Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells.

Sci Rep. 2019 Feb 28;9(1):3068. doi: 10.1038/s41598-018-38395-5. PMID: 30816128

2017
Chijimatsu R, Ikeya M, Yasui Y, Ikeda Y, Ebina K, Moriguchi Y, Shimamura K, Hart DA, Yoshikawa H and Nakamura N.
Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair.

Stem Cells Int. 2017;2017:1960965. doi: 10.1155/2017/1960965. Epub 2017 May 10.

Horikiri T, Ohi H, Shibata M, Ikeya M, Ueno M, Sotozono C, Kinoshita S, Sato T.
SOX10-Nano-Lantern Reporter Human iPS Cells; A Versatile Tool for Neural Crest Research.

PLoS One. 2017 Jan 20;12(1):e0170342. doi: 10.1371/journal.pone.0170342. eCollection 2017.

2016
Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S.
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13057-13062. Epub 2016 Oct 28.

2015
Oceguera-Yanez F, Kim SI, Matsumoto T, Tan GW, Xiang L, Hatani T, Kondo T, Ikeya M, Yoshida Y, Inoue H, Woltjen K.
Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives.

Methods. 2016 May 15;101:43-55. doi: 10.1016/j.ymeth.2015.12.012. Epub 2015 Dec 18.

Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J.
SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier.

PLoS One. 2015 Nov 16;10(11):e0142991. doi: 10.1371/journal.pone.0142991. eCollection 2015.

Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J.
Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.

PLoS One. 2015 Jul 10;10(7):e0131998. doi: 10.1371/journal.pone.0131998. eCollection 2015.

2013
Tanaka A, Woltjen K, Miyake K, Hotta A, Ikeya M, Yamamoto T, Nishino T, Shoji E, Sehara-Fujisawa A, Manabe Y, Fujii N, Hanaoka K, Era T, Yamashita S, Isobe K, Kimura E, Sakurai H
Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro

PLoS One. 2013 Apr 23;8(4):e61540. doi: 10.1371/journal.pone.0061540. Print 2013.

2010以前
Arakawa A, Matsuo-Takasaki M, Takai A, Inomata H, Matsumura M, Ikeya M, Takahashi K, Miyachi Y, Sasai N, Sasai Y.
The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo.

Dev. Biol. 306, 160-169 (2007)

Sakuragi M, Sasai N, Ikeya M, Kawada M, Onai T, Katahira T, Nakamura H, Sasai Y.
Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors.

Mech. Dev. 123, 114-123 (2006)

Mizuseki K, Sakamoto T, Watanabe K, Muguruma K, Ikeya M, Nishiyama A, Arakawa A, Suemori H, Nakatsuji N, Kawasaki H, Murakami F, Sasai Y.
Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells.

Proc. Natl. Acad. Sci. U S A. 100, 5828-5833 (2003)

Muroyama Y, Fujihara M, Ikeya M, Kondoh H, Takada S.
Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord.

Genes Dev. 16, 548-553 (2002)

Nomi M, Oishi I, Kani S, Suzuki H, Matsuda T, Yoda A, Kitamura M, Itoh K, Takeuchi S, Takeda K, Akira S, Ikeya M, Takada S, Minami Y.
Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.

Mol. Cell. Biol. 21, 8329-8335 (2001)

Kawauchi T, Ikeya M, Takada S, Ueda K, Shirai M, Takihara Y, Kioka N, Amachi T.
Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal.

Mech. Dev. 106, 147-150 (2001)

Matsuda T, Nomi M, Ikeya M, Kani S, Oishi I, Terashima T, Takada S, Minami Y.
Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.

Mech. Dev. 105, 153-156 (2001)

Takeuchi S, Takeda K, Oishi I, Nomi M, Ikeya M, Itoh K, Tamura S, Ueda T, Hatta T, Otani H, Terashima T, Takada S, Yamamura H, Akira S, Minami Y.
Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.

Genes Cells. 5, 71-78 (2000)

英語総説

Gao P, Kajiya M, Motoike S, Ikeya M, Yang J.
Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges.

Jpn Dent Sci Rev. 2024 Dec;60:95-108. doi: 10.1016/j.jdsr.2024.01.001. Epub 2024 Jan 25. PMID: 38314143 Free PMC article. Review. [Journal HP]

Ikeguchi R, Aoyama T, Tanaka M, Noguchi T, Ando M, Yoshimoto K, Sakamoto D, Iwai T, Miyazaki Y, Akieda S, Ikeya M, Nakayama K, Matsuda S.
Nerve regeneration using the Bio 3D nerve conduit fabricated with spheroids.
J Artif Organs. 2022 Aug 15. doi: 10.1007/s10047-022-01358-9. Online ahead of print. PMID: 35970971 Review. [Journal HP]

Gao P, Liu S, Wang X, Ikeya M.
Dental applications of induced pluripotent stem cells and their derivatives.

Jpn Dent Sci Rev. 2022 Nov;58:162-171. doi: 10.1016/j.jdsr.2022.03.002. Epub 2022 Apr 30. PMID: 35516907. Review. [Journal HP]

Ventura F, Williams E, Ikeya M, Bullock AN, Ten Dijke P, Goumans MJ, Sanchez-Duffhues G.

Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva.

Biomedicines. 2021 Feb 19;9(2):213. doi: 10.3390/biomedicines9020213. PMID: 33669809 Review. [Journal HP]

Nakajima T, Ikeya M.
Development of pluripotent stem cell-based human tenocytes.
Dev Growth Differ. 2020 Dec 3. doi: 10.1111/dgd.12702. Online ahead of print. PMID: 33270251 Review. [Journal HP]

Ikeya M.

iPS cells for incurable disease

SciTech Europa 2019 Jun 5; Issue 31; 198-199 (Review) [Journal HP]

Nakajima T, Ikeya M.

Insights into the biology of fibrodysplasia ossificans progressiva using patient-derived induced pluripotent stem cells.
Regen Ther. 2019 May 10;11:25-30. doi: 10.1016/j.reth.2019.04.004. eCollection 2019 Dec. Review. PMID: 31193176 [Journal HP]

Ikeya M.
Diagnosis of fibrodysplasia ossificans progressiva (FOP) using IPS technology
Imapct 2018 Dec 1; Volume 2018, Number 12, pp. 64-66(3) doi: 10.21820/23987073.2018.12.64 (Review) [Journal HP]

Zhao C and Ikeya M.
Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells.
Stem Cells Int. 2018 Jul 31; 2018:9601623. doi: 10.1155/2018/9601623. (Review) [Journal HP]

Ikeya M, Lee SM, McMahon AP, and Takada S.
The role of Wnt signaling in the Developing Dorsal Neural Tube

Keio University Symposia for Life Science and Medicine, Vol.2 Neural Development,37-41, Springer-Verlag Tokyo (1999)

日本語総説

戸口田淳也, 日野恭介，池谷　真，

特集：遺伝性疾患治療の最前線　7．進行性骨化性線維異形成症（FOP）

遺伝子医学 32号　2020年4月1日 vol. 10 No. 2, 55-61, メディカルドゥ（2020）

中島　大輝、池谷　真
腱・人体研究のフロンティア　(4) iPS細胞と腱・靱帯研究
整形・災害外科　2020年4月1日 vol. 63 No. 4, 443-448, 金原出版株式会社 (2020)

川井俊介, 日野恭介, 池谷　真, 戸口田淳也
骨芽細胞に関する最新のトピック（2）―FOPの発症メカニズムと分子治療薬への展開―
THE BONE 2019年5月20日 Vol.33 No.1, 45-50, メディカルレビュー社

中島大輝, 池谷　真，

「iPS創薬×ドラッグリポジショニング」による進行性骨化性線維異形成症の治療薬開発
ファルマシア 2019年3月1日 vol. 55 No. 3, 199- 203, 公益社団法人日本薬学会 (2019)

池谷　真，

進行性骨化性線維異形成症の発症機構の解明

日本再生医療学会雑誌　再生医療　vol. 17 No. 4, 77-82, メディカルレビュー社 (2018)

日野恭介，戸口田淳也, 池谷　真，

FOP患者由来iPS細胞を用いた創薬

医学のあゆみ 2018年9月8日 vol. 266 No. 10, 796-797, 医歯薬出版株式会社 (2018)

日野恭介，池谷　真，
患者特異的iPS細胞由来間葉系細胞を用いた創薬スクリーニング
創薬のための細胞利用技術の最新動向と市場, 第II編第1章 6,（株）シーエムシー･リサーチ (2018)

戸口田淳也、日野恭介、池谷　真

疾患特異的iPS細胞を用いた筋・骨格系疾患に対するアプローチ

血液フロンティア 3月号 Vol.28 No.3, 79-86, 医薬ジャーナル (2018)

池谷　真，日野恭介，松本佳久，福田　誠，戸口田淳也
間葉系幹細胞疾患としての進行性骨化性線維異形成症
実験医学増刊 Vol.34 No.17, 145(2913)-151(2919), 羊土社 (2016)

日野恭介、池谷真、戸口田　淳也
患者由来iPS 細胞を用いた進行性骨化性線維異形成症（FOP）の病態解明
感染　炎症　免疫, 第46巻　第1号, 55‐58, 鳥居薬品株式会社（2016）

松本佳久、日野恭介、池谷真、戸口田淳也
iPS細胞を用いた進行性骨化性線維異形成症の病態解明
バイオサイエンスとインダストリー, 第74巻　第4号, 324‐326, 一般財団法人バイオインダストリー協会（2016）

戸口田淳也、日野恭介、池谷真

疾患特異的iPS細胞を活用した難病研究～病態解明から創薬へ

CLINICAL CALCIUM, Vol.26 No.4: 593-600,株式会社医薬ジャーナル社（2016）

松本佳久、池谷真、横山宏司、大塚隆信、戸口田淳也
iPS細胞を用いた難治性骨軟骨性疾患への取り組み
日本整形外科学会雑誌, 第89巻　第12号, 1005‐1009, 公益社団法人　日本整形外科学会（2015）

戸口田淳也、横山宏司、池谷真、平家俊男、西小森隆太
慢性自己炎症性疾患における成長軟骨板の病態

臨床免疫・アレルギー科, 64(2): 205-211, 科学評論社（2015）

戸口田淳也、横山宏司、池谷　真、平家俊男、西小森隆太
疾患特異的iPS細胞を活用した筋骨格系難病研究

日本臨牀73巻　増刊号5 再生医療、416-422、日本臨牀社（2015）

戸口田淳也、池谷　真、西小森隆太
疾患特異的iPS細胞を活用した骨軟骨疾患研究

病理と臨床 2015年6月号（33巻6号）病理医を誘うiPS細胞を使った疾患研究, 599-606, 文光堂（2015）

戸口田淳也、池谷　真
患者由来iPS細胞を用いた疾患モデル作製研究：骨軟骨疾患
医学のあゆみ　Vol.252 No.12、iPS細胞研究最前線ー疾患モデルから臓器再生まで、1245-1250、医歯薬出版（2015）

池谷　真、松本佳久、戸口田淳也
進行性骨化性線維異形成症
遺伝子医学MOOK 27号, 203-207, メディカルドゥ（2015）

戸口田淳也、池谷　真、西小森隆太、松本佳久、横山宏司
疾患特異的iPS細胞を用いた難治性骨軟骨疾患の病態解析・創薬
実験医学増刊　Vol.33 No.2、再生医療2015 幹細胞と疾患iPS細胞の研究最前線、147-151、羊土社（2015）

戸口田淳也、福田誠、池谷　真
Special Review　間葉系幹細胞を巡る最近の進歩について
細胞工学　Vol.33 No.12、1282-1287、秀潤社 (2014)

松本佳久、池谷　真、戸口田淳也
骨への分化誘導
実験医学別冊　ES・iPS細胞実験スタンダード、246-257、羊土社（2014）

松本佳久、福田　誠、池谷　真、戸口田淳也
iPS細胞の基礎と応用(第3回)iPS細胞を使う : 骨の研究へ
整形外科 64(9)、1017-1019、南江堂（2013）

池谷　真、松本佳久、横山宏司、戸口田淳也
iPS細胞ーその基礎と臨床応用に向けた展望ー
整形・災害外科第56巻第5号、４月臨時増刊号、507-514、金原出版株式会社（2013）

松本佳久、池谷　真、戸口田淳也
難治性骨軟骨疾患罹患者由来iPS細胞を用いた病態再現と治療薬開発の試み
遺伝子医学MOOK 22号, 190-194, メディカルドゥ（2012）

（2010年以前）
池谷　真、川田正子
Multisite Gatewayを用いたノックアウトベクターの効率的作製法（EG construction法）
Gatewayを用いた遺伝子導入マニュアル,75-86, シュプリンガー・ジャパン (2009)

池谷　真、高田慎治
脊椎動物の原腸形成期におけるWntシグナルの役割

細胞工学第19巻第11号, 1644-1649, 秀潤社 (2000)

池谷　真、高田慎治
脊椎動物の神経管から分泌されるWnt遺伝子と形態形成

生化学第71巻第10, 1243-1247, 日本生化学会 (1999)

池谷　真
神経系の発生におけるWntシグナルの役割

脳の科学第20巻第11号, 1245-1248, 星和書店 (1998)

著作物
戸口田淳也、池谷　真（編集）
最新疾患モデルと病態解明、創薬応用研究、細胞医薬創製研究の最前線
遺伝子医学MOOK 22号、メディカルドゥ（2012）